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IGF-I upregulation is also observed in muscle after stretch-induced myofibre hypertrophy (Czerwinski et al ., 1994) and during muscle regeneration following injury (Levinovitz et al ., 1992)

Portions upstream (443 bp) and downstream (338 bp) of the GDH2 gene were amplified and fused with the 5269 bp SAT1 fragment to form a disruption cassette (~6 kb) for GDH2 gene deletion (Supplementary Fig

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It is known to participate in the neutralization of free radicals and reactive oxygen compounds as well as maintain exogenous antioxidants such as vitamins C and E in their active forms [17]

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