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Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

Eli Lilly has seven additional TRIUMPH Phase 3 readouts expected in 2026

3.2 The REWIND Trial The REWIND trial was a double-blind, randomized, placebo-controlled study conducted to evaluate the effects of dulaglutide on cardiovascular outcomes in 9901 patients with T2DM