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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

This phase determines who continues versus who quits

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Key Takeaways: GLP-1 vs GIP Both are incretin hormones released by your intestines after eating GLP-1 primarily affects appetite, gastric emptying, and insulin secretion GIP influences insulin secretion, glucagon regulation, and fat metabolism Single GLP-1 agonists (semaglutide) produce 14.9% average weight loss Dual GLP-1/GIP agonists (tirzepatide) produce 22.5% average weight loss The dual action appears to create additive rather than merely overlapping effects Both receptor types play important roles in metabolic regulation Understanding the difference helps explain why tirzepatide shows superior results What Are Incretin Hormones

Patients who want to reduce or stop medication should work with a physician to create a structured plan rather than relying on willpower alone

In clinical trials, retatrutide has shown larger average weight reductions (~30%) than tirzepatide (~21%) or semaglutide (~15%), which researchers attribute to its additional glucagon receptor activity