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Your brain is says, this is dangerous for us
The N-terminal -helix governs membrane-mediated aggregation by anchoring the protein into the membrane ( -helix formation followed by membrane damage have been observed for at least two other amyloidogenic proteins: -synuclein, linked to Parkinsons disease ( Mitochondrial dysfunction in the striatum is a primary feature of Huntingtons disease ( -helix in the synapses within the striatum is an important factor facilitating mitochondrial dysfunction
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A specific type of TRx (f-type) has been shown to be glutathionylated on a cysteine residue away from its active site, resulting in a decreased activity towards specific target proteins including NADP-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [189]
MP: Data collection, assistance in study design and data interpretation
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