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Early procedures, like intestinal bypasses and open gastric bypasses in the 1960s, helped patients lose a lot of weight but came with serious risks

Nature 514 , 4753 (2014)

DO NOT use prescription appetite stimulants or high-calorie supplements for treatment of anorexia or cachexia (unexplained wasting) in older adults

Metabolic changes favor the activity and heterogeneity of reactive astrocytes

Major weight loss and improved metabolic health can enhance sexual function through several pathways