(2016) used a conditional mutant to show TrxR targeting reduced bacterial burden in a mouse infection model, concluding that auranofin targets TrxB2 but acknowledge this may not be the only enzyme affected
Conceptualization: AD, EG Methodology: AD, EG, AG, HS, JC, MLV, PLC, CC, TG, OF, AMK, CL, BJ Investigation: AD, EG, AG, MLV, HS, TG, OF, DK Visualization: AD, EG, AG, HS Funding acquisition: AD, RB, GWM Project administration: AD, RB, GWM Supervision: AD Writing original draft: AD, EG Writing review & editing: AD, EG, AG, HS, JC, MLV, PLC, CC, TG, OF, AMK, CL, DK, RB, GWM Competing interests Authors declare that they have no competing interests
We stained serial sections with 6 antibodies alternating with stainings for A and p-Tau routinely used for AD diagnosis, to be able to perform correlation analysis later on
Many compounds, like ZEA, DON, or OTA, are efficiently made non-toxic by the microorganisms of the rumen prior to absorption (Cavret and Lecoeur, 2006)
Homocysteine and disease: Causal associations or epiphenomenons
It is well established that dissolved organic matter is a component of sea spray aerosol 79,80,81