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2l, m), whereas both constructs showed progressive changes upon Palmostatin B addition

Moreover, NUAK1 inhibition causes tumor ICD through H 2 O 2 /OH accumulation and ER stress, as NRF2, downstream of NUAK1, suppresses antioxidant gene expression [263]

The catalytic cycle of Grx2 is also quite similar to Grx1 except that the Grx2SSG intermediate can be reduced by NADPH and TrxRD

These multi-target actions position SFN as a promising nutraceutical candidate for NAFLD therapy (55)

Conclusions As mentioned above, an increasing number of studies in recent years have led to a better understanding of the complex functions of p53 in different contexts, including the fundamental regulation, function, and therapeutic potential of p53

An overview of molecular basis of iron metabolism regulation and the associated pathologies