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The process of food intake, previously seen as a purely physiologic state of energy homeostasis, is a product of a complex interaction that starts with stomach mechanoreceptors, involving peptide release for stimuli of hunger and satiation (depending on food quantity), peristalsis and gastric accommodation (8387)

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Studies and clinical trials show that when people stop taking GLP-1s, the appetite often comes back, and in many cases there is rapid weight regain, especially if nutrition and behavior changes werent made when on the medication, she says

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The massive weight-loss numbers you see in commercials, 15% to 20% body-weight loss, come from high therapeutic doses in controlled clinical trials